Green-Synthesized SeO/ZnO Nanocomposites from Musa acuminata Peel: Implications for Anticancer and Antimicrobial Strategies in Public Health

Nada H. Aljarba; Hamida Hamdi; Luluah M. Al Masoudib; Noha T. Al Thagafib; Ashwaq T. Althobaiti; Dalal M. Alkuraythi; Dina A. Altwiley; Adil Abalkhail; Mohamed K. Y. Soliman

Authors

Nada H. Aljarba Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia https://orcid.org/0000-0001-9224-8844
Hamida Hamdi Department of Biology, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia. Zoology Department, Faculty of Science, Cairo University, Giza 12613, Egypt https://orcid.org/0000-0002-1457-7201
Luluah M. Al Masoudib Department of Biology, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia https://orcid.org/0000-0001-6485-5882
Noha T. Al Thagafib Department of Biology, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia https://orcid.org/0009-0009-9271-0301
Ashwaq T. Althobaiti Department of Biology, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia https://orcid.org/0009-0002-9887-2765
Dalal M. Alkuraythi Department of Biological Sciences, University of Jeddah, Jeddah, Saudi Arabia https://orcid.org/0000-0002-8544-4393
Dina A. Altwiley Department of Biological Sciences, University of Jeddah, Jeddah, Saudi Arabia. https://orcid.org/0009-0008-0917-3422
Adil Abalkhail Department of Public Health, College of Applied Medical Sciences, Qassim University, P.O. Box 6666, 51452 Buraydah, Saudi Arabia. https://orcid.org/0000-0002-2294-9837
Mohamed K. Y. Soliman Botany and Microbiology Department, Faculty of Science, Al-Azhar University, Nasr City 11884, Cairo, Egypt

Keywords:

SeO/ZnO NCs, Green synthesis, Anticancer activity, Antibacterial activity, Antioxidant activity

Abstract

An eco-friendly one-pot approach was employed to biosynthesize selenium oxide/zinc oxide (SeO/ZnO) nanocomposites using banana peel (Musa acuminata L.) extract. The phytogenic nanocomposite was characterized using FTIR, UV–Vis spectroscopy, TEM, SEM, and EDX analyses. A distinct absorbance peak at 336 nm confirmed nanocomposite formation, while FTIR results indicated the involvement of plant phytochemicals in stabilization and surface functionalization processes. TEM images revealed quasi-spherical nanoparticles with an average diameter of 64 nm. Elemental analysis (EDX) confirmed the presence of selenium and zinc, suggesting that selenium is predominantly present in oxide form (SeO) within the ZnO matrix. Biological evaluations showed significant multifunctional activity. The SeO/ZnO nanocomposite exhibited selective antiproliferative activity against A549 lung cancer cells (IC₅₀ = 100.9 µg/mL) compared to normal Vero cells (IC₅₀ = 263.5 µg/mL), indicating favorable selectivity. Pronounced antibacterial activity was observed, particularly against Bacillus subtilis (MIC = 62.5 µg/mL; inhibition zone = 27.8 ± 0.75 mm). Concentration-dependent antioxidant activity was confirmed using DPPH and ABTS assays, with IC₅₀ values of 256.8 and 339.40 µg/mL, respectively.

Green-Synthesized SeO/ZnO Nanocomposites from Musa acuminata Peel: Implications for Anticancer and Antimicrobial Strategies in Public Health

Authors

Keywords:

Abstract

Downloads

Published

How to Cite

Issue

Section