Nanocomposites of ZnO/CuO/Se Synthesized by Schinus terebinthifolia Biomass and their Antioxidant, Cytotoxicity, Anti-H. pylori, and Anti-obesity Properties

Authors

  • Mohanned T. Alharbi Department of Basic Medical Sciences, College of Medicine, University of Jeddah, Jeddah, Saudi Arabia https://orcid.org/0000-0003-4955-0014
  • Aisha M. H. Al-Rajhi Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia https://orcid.org/0000-0001-9595-0612
  • Mohammed S. Almuhayawi Department of Clinical Microbiology and Immunology, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia; Yousef Abdulatif Jameel Scientific Chair of Prophetic Medicine Application, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia https://orcid.org/0000-0002-4792-066X
  • Hattan S. Gattan Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia; Special Infectious Agents Unit, King Fahad Medical Research Center, King AbdulAziz University, Jeddah, Saudi Arabia https://orcid.org/0000-0003-3514-4912
  • Mohammed H. Alruhaili Department of Clinical Microbiology and Immunology, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia; Special Infectious Agents Unit, King Fahad Medical Research Center, King AbdulAziz University, Jeddah, Saudi Arabia https://orcid.org/0000-0001-8114-7212
  • Yahya Ali Department of Biology, College of Science, Jazan University, P.O. Box 114, Jazan 45142, Saudi Arabia; Department of Clinical Laboratory Sciences,College of Applied Medical Sciences, Jouf University, Sakaka 72388, Saudi Arabia https://orcid.org/0009-0009-7939-2556
  • Samy Selim Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka 72388, Saudi Arabia https://orcid.org/0000-0003-4025-8586

Keywords:

Nanocomposite, Schinus terebinthifolia, Anti-obesity, Antimicrobial activity

Abstract

A watery extract of Schinus terebinthifolia leaves was used as the source for producing a nanocomposite of ZnO/CuO/Se (NC ZnO/CuO/Se). Transmission electron microscopy (TEM), UV, X-ray diffraction, and scanning electron microscopy-energy were employed to characterize NC ZnO/CuO/Se. Based on the TEM investigation, the nanoparticles had an average size between 40.9 and 50.2 nm. NC ZnO/CuO/Se had potent anti-H. pylori activity, as evidenced by a zone of inhibition of 34.3 mm. The NC ZnO/CuO/Se successfully inhibited H. pylori (MIC = 15.6 μg/mL) and showed better antimicrobial activity in comparison with the control. At 75% of MBC, it dramatically decreased the production of bacterial biofilms (91.1% inhibition). High antioxidant qualities were demonstrated by the NC ZnO/CuO/Se (> 88% in the DPPH assay). It demonstrated outstanding enzyme inhibition capacity against lipase, with an IC50 of 41.66 ug/mL. The IC50 value of NC ZnO/CuO/Se against normal cell lines (WI38) was 593.08 ± 2.35  µg mL–1, which is a high dose. From the overall results, NC ZnO/CuO/Se exhibited favorable biological effects in vitro as a wide-spectrum treatment for various medical uses.

Downloads

Published

2025-04-25 — Updated on 2025-04-30

How to Cite

Alharbi, M. T., Al-Rajhi, A. M. H., Almuhayawi, M. S., Gattan, H. S., Alruhaili, M. H., Ali, Y., & Selim, S. (2025). Nanocomposites of ZnO/CuO/Se Synthesized by Schinus terebinthifolia Biomass and their Antioxidant, Cytotoxicity, Anti-H. pylori, and Anti-obesity Properties. BioResources, 20(2), 4432–4449. Retrieved from https://ojs.bioresources.com/index.php/BRJ/article/view/24528

Issue

Vol. 20 No. 2 (2025)

Section

Research Article or Brief Communication